Forums › Other Topics › Off Topic › Treatment of Intrabony Pockets with Emdogain: Results at 36
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AnonymousGuestI know the Periolase users have seen this but I thought I’d put it up for all.
International Journal of Periodontics and Restorative Dentistry
January/February
Volume 24, Issue 1Treatment of Intrabony Pockets with Emdogain: Results at 36 Months
Renato Parodi, MD, DMD/Giorgio A. E. Santarelli, MD, DMD/Bruno Gasparetto, EE
This study reports the results obtained 36 months after treating deep periodontal defects with amelogenins. Results at 12 months have already been published. Sixteen of 21 patients completed the 3-year recall program. This study confirms after 3 years the results obtained at 1 year: Probing pocket depth decreased from 7.87 ± 2.03 mm to 2.93 ± 2.19 mm; recession increased from 2.20 ± 1.42 mm to 2.93 ± 1.87 mm; and attachment level decreased from 10.07 ± 2.28 to 5.87 ± 2.59 mm. No statistically significant difference was found between the data collected at 12 and 36 months. The standardized radiographs, digitized and analyzed with purpose- developed software, did not show any appreciable increase in bone volume, but only improved mineralization of the preexisting bone after 3 years using Emdogain without grafts.
(Int J Periodontics Restorative Dent 2004;24:57–63.)
lookin4tSpectatorThere are more articles that support bone growth, and the company will readily admit it takes about a year for bone growth to show radiographically…and may continue to show over time. Hujoel has many cases documented over time showing this.
What is shown here is counter to the preponderance of evidence.
However, some people do add bone to the emdogain. Cochran goes around showing why adding DFDBA may be a good idea, and supports the use of mFDBA as well and hinted he is looking at it.
Leckovic has an article supporting the use of BPPM with emdogain, but the surgical technique was not good and overall results too poor to seriously go by this study.
Sculean and Cochran would be two good authors to look up. Windisch has one 6 months out that says there is less bone with emdogain compared to a membrane, the key being that follow up is at 6 months. I think you will find the prepoderance of the evidence does not support the finding underlined in the study you quoted.
Glenn van AsSpectatorLookin4t: welcome to the LDF site and its great to have your knowledge here on periodontal therapy. I know that Ron has been using the Periolase MVP-7 for his periodontal patients in an effort to decrease the pocket depths that are present.
I know that Andy and Danny have both spent some time discussing this on the forum and mentioning that they are quite excited as periodontists to see lasers and Bob Greggs protocol having a positive effect for the periodontal discipline.
There is now evidence from Ray Yukna’s study to support pocket reduction through the LPT protocol and the Periolase MVP -7 by bone regeneration instead of long junctional epithelium.
I myself do not have this laser or own any stock in the product but wonder as a periodontist (which I assume you are) if you have any opinions regarding what Bob and Del and the rest of the Periolase users are doing.
This goes against what the AAP is promoting in their stance against lasers.
I myself find it exciting to see the growing number of periodontists who are coming to this site or lectures involving lasers to see if there is the possibility that they may be of benefit in their practice.
What do you think?
Glenn
AnonymousGuestQUOTEQuote: from lookin4t on 1:41 am on June 6, 2004
… the company will readily admit it takes about a year for bone growth to show radiographically…What is shown here is counter to the preponderance of evidence.
Since this is a 3 year follow up do you have any input as to why this might run contrary to the ‘preponderance of evidence’?
Thanks for your input,
lookin4tSpectatorIn regard to contrary to the preponderance of the evidence:
I would have to go back and read materials and methods on this study to see why. When I commented on the preponderance of the evidence, it referred to the fact that the majority of studies don’t reflect what this one does. Most of the time, it is a methods quirk. I know that the data on showing bone fill over time appears to be solid.
Regarding the AAP position…similar topic at DT. The AAP position paper is based on available evidence and to that extent, it is accurate from a clinical study point. There are flaws in the paper I believe you are referring to in regard to the physics of lasers. The people I run with in the AAP are not against lasers for vindictive reasons, they do push for an evidence base to what we do. I would do just about anything that helped my patients with good reason to do so. I think Bob Gregg may make a believer out of the AAP….because he is trying to provide the evidence.
I sincerely respect what Dr. Gregg is doing with his company and communicate with him on occasion. I don’t think diodes are the answer, or he would not have put his own money forward to make a free running pulsed laser for dental applications. In all honesty, it is the one laser I could see myself owning if the multi-center study verifies everything. I would like to know how it has worked in furcation defects as I haven’t seen him show any that regrew bone there.
I’m a periodontist…we’ve talked before, I sent you a PM-to Ron, and communicated with Glenn….we’ve “met” each other before.
I hope to be a good contributing member…and I hope to learn more about lasers. I have some additional responsibility recently placed on me that may require it in addition to my own personal interest. Besides, there have been few useful laser posts at DT in quite awhile.
Robert Gregg DDSSpectatorHey Lookin4t……
I got your furca-fill right here………
Well, just as soon as I can post ’em.
Seriously, it does work in furcations.
In our upcoming clinical study, we have included furcations as part of the inclusion criteria. The study investigators–Yukna and Cobb–suggested we leave molar furcas out of the study since “nothing” works for them. When Del and I said we wanted them in, there was stunned silence followed by excited enthusiasm.
And thanks very much for the kind words. It is much appreciated. We are trying to provide the evidence. As a small company that refuses VC capital infusion (to stay true to our mission of science and company control) it takes us longer to fund a large study while we are “bootstrapping” it. But we are working on it.
I’ll be in Boston this coming weekend for the 8th Annual International Perio and Restorative meeting. Prof Yukna will be presenting his human Laser ANAP histology.
Cheers,
Bob
lookin4tSpectatorI sure hope when you said furcation you were referring to teeth
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